Obesity is becoming the major epidemic of the 21st century, and we are studying this disease in an integrated way - from the perspective of genomics, microbiomics, and epigenomics. We are following a large group of newborn children until they are at least 3 years of age, and will be finding genes linked to the development of obesity in some of them. This collaboration includes clinicians, statisticians, and social scientists to obtain a multifaceted picture of this important phenotype. Collaborators: Ian Paul, Francesca Chiaromonte.
Research Assistant Professor
UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help …
Millions of tiny dots litter the canvas, each independently just a splotch of unmixed pigment but together a masterpiece of illusion …
The composition of oral microbiota – the collection of microorganisms, including beneficial bacteria, residing in the mouth …
JS Savage, AK Hochgraf, E Loken, ME Marini, SJ Craig, KD Makova, LL Birch, IM Paul. INSIGHT responsive parenting educational intervention for firstborns is associated with growth of secondborn siblings. OBESITY, 2022.
D Nandy, SJ Craig, J Cai, Y Tian, IM Paul, JS Savage, ME Marini, EE Hohman, ML Reimherr, AD Patterson, KD Makova, F Chiaromonte. Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes. PED OBESITY, 2022.
SJ Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, ML Reimherr, KD Makova. Constructing a polygenic risk score for childhood obesity using functional data analysis. ECON STAT, 2021.
MC Carney, X Zhan, A Rangnekar, MZ Chroneos, SJ Craig, KD Makova, IM Paul, SD Hicks. Associations between stool micro-transcriptome, gut microbiota, and infant growth. J DEV ORIG HLTH DIS, 2021.
SJC Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, M Reimherr, KD Makova. Polygenic risk score based on weight gain trajectories is a strong predictor of childhood obesity. BIORXIV, 2019.
SJC Craig, D Blankenberg, ACL Parodi, IM Paul, LL Birch, JS Savage, ME Marini, JL Stokes, A Nekrutenko, M Reimherr, F Chiaromonte, KD Makova. Child Weight Gain Trajectories Linked To Oral Microbiota Composition. SCI REP-UK, 2018.
IM Paul, JS Williams, S Anzman-Frasca, JS Beiler, KD Makova, ME Marini, LB Hess, SE Rzucidlo, N Verdiglione, JA Mindell, LL Birch. The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study. BMC PEDIATR, 2014.