Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network
Abstract
While gene duplication is known to be one of the most common mechanisms of genome evolution, the fates of genes after duplication are still being debated. In particular, it is presently unknown whether most duplicate genes preserve (or subdivide) the functions of the parental gene or acquire new functions. One aspect of gene function, that is the expression profile in gene coexpression network, has been largely unexplored for duplicate genes.
Type
Publication
BMC Bioinformatics
Authors
Prof. Nekrutenko performed postdoctoral work at the University of Chicago where he found his interest in computational genomics. After moving to the Pennsylvania State University as an Assistant Professor, he and his collaborators developed the Galaxy platform for analysis of biological data. He is now a professor of biochemistry and molecular biology and founding member of galaxyproject.org.
Authors
Professor
Kateryna is interested in genomics, evolution, and human genetics.
Her lab studies mutations using both computational and experimental
approaches. Additional topics of interest include sex chromosome
evolution and genomics of childhood obesity.