Obesity is becoming the major epidemic of the 21st century, and we are studying this disease in an integrated way - from the perspective of genomics, microbiomics, and epigenomics. We are following a large group of newborn children until they are at least 3 years of age, and will be finding genes linked to the development of obesity in some of them. This collaboration includes clinicians, statisticians, and social scientists to obtain a multifaceted picture of this important phenotype. Collaborators: Ian Paul, Francesca Chiaromonte.
Childhood obesity
Collaborators
Press Releases
New approach can help identify young children most at risk for obesity
UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help …
Connecting the dots
Millions of tiny dots litter the canvas, each independently just a splotch of unmixed pigment but together a masterpiece of illusion …
Young children’s oral bacteria may predict obesity
The composition of oral microbiota – the collection of microorganisms, including beneficial bacteria, residing in the mouth …
Publications
D Lariviere, SJC Craig, IM Paul, E Hohman, JS Savage, RO Wright, F Chiaromonte, KD Makova, ML Reimherr.
Methylation profiles at birth linked to early childhood obesity.
Accepted for publication by the Journal of Developmental origins of Health and Disease and is currently in press,
2024.
SJC Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, ML Reimherr, KD Makova.
Constructing a polygenic risk score for childhood obesity using functional data analysis.
Econom Stat,
2023.
JS Savage, AK Hochgraf, E Loken, ME Marini, SJ Craig, KD Makova, LL Birch, IM Paul.
INSIGHT responsive parenting educational intervention for firstborns is associated with growth of secondborn siblings.
OBESITY,
2022.
D Nandy, SJ Craig, J Cai, Y Tian, IM Paul, JS Savage, ME Marini, EE Hohman, ML Reimherr, AD Patterson, KD Makova, F Chiaromonte.
Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes.
PED OBESITY,
2022.
SJ Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, ML Reimherr, KD Makova.
Constructing a polygenic risk score for childhood obesity using functional data analysis.
ECON STAT,
2021.
MC Carney, X Zhan, A Rangnekar, MZ Chroneos, SJ Craig, KD Makova, IM Paul, SD Hicks.
Associations between stool micro-transcriptome, gut microbiota, and infant growth.
J DEV ORIG HLTH DIS,
2021.
SJC Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, M Reimherr, KD Makova.
Polygenic risk score based on weight gain trajectories is a strong predictor of childhood obesity.
BIORXIV,
2019.
SJC Craig, D Blankenberg, ACL Parodi, IM Paul, LL Birch, JS Savage, ME Marini, JL Stokes, A Nekrutenko, M Reimherr, F Chiaromonte, KD Makova.
Child Weight Gain Trajectories Linked To Oral Microbiota Composition.
SCI REP-UK,
2018.
IM Paul, JS Williams, S Anzman-Frasca, JS Beiler, KD Makova, ME Marini, LB Hess, SE Rzucidlo, N Verdiglione, JA Mindell, LL Birch.
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study.
BMC PEDIATR,
2014.