Childhood obesity

Obesity is becoming the major epidemic of the 21st century, and we are studying this disease in an integrated way - from the perspective of genomics, microbiomics, and epigenomics. We are following a large group of newborn children until they are at least 3 years of age, and will be finding genes linked to the development of obesity in some of them. This collaboration includes clinicians, statisticians, and social scientists to obtain a multifaceted picture of this important phenotype. Collaborators: Ian Paul, Francesca Chiaromonte.

Collaborators

Press Releases

UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help …

Millions of tiny dots litter the canvas, each independently just a splotch of unmixed pigment but together a masterpiece of illusion …

The composition of oral microbiota – the collection of microorganisms, including beneficial bacteria, residing in the mouth …

Publications

. Methylation profiles at birth linked to early childhood obesity. Accepted for publication by the Journal of Developmental origins of Health and Disease and is currently in press, 2024.

Childhood Obesity Paper Link

. Constructing a polygenic risk score for childhood obesity using functional data analysis. Econom Stat, 2023.

Childhood Obesity Paper Link

. INSIGHT responsive parenting educational intervention for firstborns is associated with growth of secondborn siblings. OBESITY, 2022.

Childhood Obesity Paper Link

. Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes. PED OBESITY, 2022.

Childhood Obesity Paper Link

. Constructing a polygenic risk score for childhood obesity using functional data analysis. ECON STAT, 2021.

Childhood Obesity Paper Link

. Associations between stool micro-transcriptome, gut microbiota, and infant growth. J DEV ORIG HLTH DIS, 2021.

Childhood Obesity Paper Link

. Polygenic risk score based on weight gain trajectories is a strong predictor of childhood obesity. BIORXIV, 2019.

Childhood Obesity Paper Link

. Child Weight Gain Trajectories Linked To Oral Microbiota Composition. SCI REP-UK, 2018.

Childhood Obesity Paper Link Press Release

. The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study. BMC PEDIATR, 2014.

Childhood Obesity Paper Link