Fig 1: Enrichment plot: HALLMARK_UV_RESPONSE_DN
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | de_results_collapsed |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_pos |
| GeneSet | HALLMARK_UV_RESPONSE_DN |
| Enrichment Score (ES) | 0.23909831 |
| Normalized Enrichment Score (NES) | 1.1518226 |
| Nominal p-value | 0.2798165 |
| FDR q-value | 0.41508266 |
| FWER p-Value | 0.983 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PDGFRB | platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] | 14 | 8.393 | 0.0820 | Yes |
| 2 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 19 | 8.193 | 0.1670 | Yes |
| 3 | TGFBR3 | transforming growth factor beta receptor 3 [Source:HGNC Symbol;Acc:HGNC:11774] | 133 | 5.659 | 0.1692 | Yes |
| 4 | SLC7A1 | solute carrier family 7 member 1 [Source:HGNC Symbol;Acc:HGNC:11057] | 218 | 4.898 | 0.1781 | Yes |
| 5 | GRK5 | G protein-coupled receptor kinase 5 [Source:HGNC Symbol;Acc:HGNC:4544] | 290 | 4.587 | 0.1904 | Yes |
| 6 | LDLR | low density lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:6547] | 291 | 4.583 | 0.2391 | Yes |
| 7 | RASA2 | RAS p21 protein activator 2 [Source:HGNC Symbol;Acc:HGNC:9872] | 478 | 3.923 | 0.1854 | No |
| 8 | FYN | "FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037]" | 621 | 3.619 | 0.1509 | No |
| 9 | ERBB2 | erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430] | 649 | 3.564 | 0.1750 | No |
| 10 | SYNE1 | spectrin repeat containing nuclear envelope protein 1 [Source:HGNC Symbol;Acc:HGNC:17089] | 713 | 3.468 | 0.1795 | No |
| 11 | PIAS3 | protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861] | 811 | 3.295 | 0.1647 | No |
| 12 | F3 | "coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541]" | 812 | 3.292 | 0.1997 | No |
| 13 | ID1 | "inhibitor of DNA binding 1, HLH protein [Source:HGNC Symbol;Acc:HGNC:5360]" | 840 | -3.296 | 0.2209 | No |
| 14 | DUSP1 | dual specificity phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:3064] | 1038 | -3.603 | 0.1581 | No |
| 15 | LAMC1 | laminin subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:6492] | 1060 | -3.625 | 0.1858 | No |
| 16 | ZMIZ1 | zinc finger MIZ-type containing 1 [Source:HGNC Symbol;Acc:HGNC:16493] | 1083 | -3.666 | 0.2135 | No |
| 17 | CDC42BPA | CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737] | 1547 | -4.728 | 0.0262 | No |
| 18 | PRKCA | protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] | 1614 | -4.933 | 0.0447 | No |
| 19 | PMP22 | peripheral myelin protein 22 [Source:HGNC Symbol;Acc:HGNC:9118] | 1723 | -5.300 | 0.0456 | No |
| 20 | IGF1R | insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465] | 1937 | -7.489 | 0.0159 | No |
