UNIVERSITY PARK, Pa. — Unlike other tissues in the human body, human eggs don’t pick up as many mutations in some of their DNA as they age. The findings from a new study, published …
UNIVERSITY PARK, Pa. — Certain DNA sequences can form structures other than the canonical double helix. These alternative DNA conformations — referred to as non-B DNA — have been …
UNIVERSITY PARK, Pa. — Differences among the DNA of seven ape species — including humans — are greater than originally thought, according to an international team led by …
Newly generated, complete “end-to-end” reference genomes for the sex chromosomes of five great ape species and one lesser ape species — produced by an international collaborative …
Listen to the Science Friday podcast where Adam Phillippy and Kateryna Makova discuss the challenges of sequencing the Y chromosome, and what doing so might mean for medical …
New mutations occur at increasing rates in the mitochondrial genomes of developing egg cells in aging rhesus monkeys, but the increases appear to plateau at a certain age and are …
UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help clinicians identify young children most at risk …
Some regions of the human genome where the DNA can fold into unusual three-dimensional structures called G-quadruplexes (G4s) show signs that they are preserved by natural …
DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research shows that the …
UNIVERSITY PARK, Pa. — New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how …