Readme

These files form the components of a book, "Working with Molecular Genetics" by Ross C. Hardison. This was used in teaching an upper level undergradudate course at Penn State University until 2002. This material is free for any use except grabbing it and publishing it for profit.

This is order intended for the individual files:

Part One Overview
Chapter 1. Fundamental properties of genes
Chapter 2. Structures of nucleic acids
Chapter 3. Isolating and analyzing genes: Recombinant DNA, PCR and what you can learn from them
Chapter 4. Genomes and chromosomes
Part One Answers
Chapter 5. Replication I: Enzymology
Chapter 6. Replication I: Start, stop and control
Chapter 7. Mutability and repair of DNA
Chapter 8. Recombination of DNA
Chapter 9. Transposition
Part Two Answers
Chapter 10. Transcription: RNA polymerases
Chapter 11. Transcription: Promoters
Chapter 12. RNA processing
Chapter 13. Genetic code
Chapter 14. Translation
Part Three Answers
Part Four Overview
Chapter 15. Positive and negative control illustrated by the lac operon
Chapter 16. Transcriptional regulation by effects on RNA polymerase
Chapter 17. Bacteriophage lambda
Chapter 18. Regulation after initation of transcription
Chapter 19. Regulation of eukaryotic genes
Chapter 20. Regulation by changes in chromatin structure
Part Four summary:  Themes in mechanisms of gene regulation
Part Four Answers