Translation of research results from mouse to human

We provide a database and query interface to transcription factor binding sites categorized by their epigenetic conservation. The categories include functional conservation in both mouse and human (FunctCons), repurposed sites (FunctActive), conserved at the genomic sequence level but not occupied in the second species (SeqCons), or lineage-specific, i.e. no orthologous sequence found in the second species. These data are from Denas et al. (2015) BMC Genomics.

We will provide a gene-by-gene assessment of the level of conservation of gene expression patterns across tissues in mouse, human, and other species. The logic for this approach is explained in this essay. We will use the results from the analyses by Breschi et al. (2016) Genome Biology, in particular the supplementary information.