ValIdated Systematic IntegratiON of hematopoietic epigenomes

Project Overview

We will (1) generate, compile, and integrate data on epigenomic landscapes and chromatin interactions to predict regulatory regions and targets, (2) use deep learning approaches to develop quantitative models for gene regulation validated experimentally at reference loci, and (3) provide a guide for translation of research insights from mouse to human. Iterative refinement should improve accuracy.